References
About EDS
Malfait, F., Castori, M., Francomano, C. A., Giunta, C., Kosho, T., & Byers, P. H. (2020). The Ehlers–Danlos syndromes. Nature Reviews Disease Primers, 6(1), 64. https://doi.org/10.1038/s41572-020-0194-9
Mamdani, F., & Mankowitz, S. K. W. (2018). Ehler-Danlos. In Consults in Obstetric Anesthesiology (pp. 179–183). Springer International Publishing. https://doi.org/10.1007/978-3-319-59680-8_50
Nelson, A. D., Mouchli, M. A., Valentin, N., Deyle, D., Pichurin, P., Acosta, A., & Camilleri, M. (2015). Ehlers Danlos syndrome and gastrointestinal manifestations: a 20-year experience at Mayo Clinic. Neurogastroenterology & Motility, 27(11), 1657–1666. https://doi.org/10.1111/nmo.12665
Frequently Asked Questions
Byers, P. H., & Murray, M. L. (2012). Heritable collagen disorders: The paradigm of the Ehlers-Danlos syndrome. The Journal of Investigative Dermatology, 132(E1), E6-11. https://doi.org/10.1038/skinbio.2012.3
Demmler, J. C., Atkinson, M. D., Reinhold, E. J., Choy, E., Lyons, R. A., & Brophy, S. T. (2019). Diagnosed prevalence of Ehlers-Danlos syndrome and hypermobility spectrum disorder in Wales, UK: A national electronic cohort study and case–control comparison. BMJ Open, 9(11), e031365. https://doi.org/10.1136/bmjopen-2019-031365
Di Giacomo, P., Celli, M., Ierardo, G., Polimeni, A., & Di Paolo, C. (2018). Evaluation of temporomandibular disorders and comorbidities in patients with ehler-–danlos: Clinical and digital findings. Journal of International Society of Preventive & Community Dentistry, 8(4), 333–338. https://doi.org/10.4103/jispcd.JISPCD_103_18
Leganger, J., Fonnes, S., Kulas Søborg, M. L., Rosenberg, J., & Burcharth, J. (2022). The most common comorbidities in patients with Ehlers-Danlos syndrome: A 15-year nationwide population-based cohort study. Disability and Rehabilitation, 44(2), 189–193. https://doi.org/10.1080/09638288.2020.1761890
Malfait, F., & De Paepe, A. (2014). The Ehlers-Danlos Syndrome. In J. Halper (Ed.), Progress in heritable soft connective tissue diseases (pp. 129–143). Springer Netherlands. https://doi.org/10.1007/978-94-007-7893-1_9
Malfait, F., Francomano, C., Byers, P., Belmont, J., Berglund, B., Black, J., Bloom, L., Bowen, J. M., Brady, A. F., Burrows, N. P., Castori, M., Cohen, H., Colombi, M., Demirdas, S., De Backer, J., De Paepe, A., Fournel-Gigleux, S., Frank, M., Ghali, N., … Tinkle, B. (2017). The 2017 international classification of the Ehlers-Danlos syndromes. American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 175(1), 8–26. https://doi.org/10.1002/ajmg.c.31552
Miklovic, T., & Sieg, V. C. (2021). Ehlers Danlos Syndrome. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK549814/
Reychler, G., De Backer, M., Piraux, E., Poncin, W., & Caty, G. (2021). Physical therapy treatment of hypermobile Ehlers–Danlos syndrome: A systematic review. American Journal of Medical Genetics Part A, 185(10), 2986–2994. https://doi.org/10.1002/ajmg.a.62393
Ritelli, M., & Colombi, M. (2020). Molecular genetics and pathogenesis of ehlers-danlos syndrome and related connective tissue disorders. Genes, 11(5), E547. https://doi.org/10.3390/genes11050547
The Ehlers Danlos Society. (n.d.). Why the zebra? https://www.ehlers-danlos.com/why-the-zebra/
Zhou, Z., Rewari, A., & Shanthanna, H. (2018). Management of chronic pain in Ehlers–Danlos syndrome. Medicine, 97(45), e13115. https://doi.org/10.1097/MD.0000000000013115
EDS and Diet, Comorbidities and Symptoms, Diet Strategies
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Barrett, J. S. (2017). How to institute the low-FODMAP diet. Journal of Gastroenterology and Hepatology, 32, 8–10. https://doi.org/10.1111/jgh.13686
Beckers, A. B., Keszthelyi, D., Fikree, A., Vork, L., Masclee, A., Farmer, A. D., & Aziz, Q. (2017). Gastrointestinal disorders in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: A review for the gastroenterologist. Neurogastroenterology & Motility, 29(8), e13013. https://doi.org/10.1111/nmo.13013
Cheshire, W. P. (2021). Salt: The paradoxical philosopher’s stone of autonomic medicine. Autonomic Neuroscience, 236, 102895. https://doi.org/10.1016/j.autneu.2021.102895
Choudhary, A., Fikree, A., & Aziz, Q. (2021). Overlap between irritable bowel syndrome and hypermobile Ehlers–Danlos syndrome: An unexplored clinical phenotype? American Journal of Medical Genetics Part C: Seminars in Medical Genetics, 187(4), 561–569. https://doi.org/10.1002/ajmg.c.31938
Chumpitazi, B. P., Lim, J., McMeans, A. R., Shulman, R. J., & Hamaker, B. R. (2018). Evaluation of FODMAP Carbohydrates Content in Selected Foods in the United States. The Journal of Pediatrics, 199, 252–255. https://doi.org/10.1016/j.jpeds.2018.03.038
de Bortoli, N., Tolone, S., Frazzoni, M., Martinucci, I., Sgherri, G., Albano, E., Ceccarelli, L., Stasi, C., Bellini, M., Savarino, V., Savarino, E. v, & Marchi, S. (2018). Gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome: common overlapping gastrointestinal disorders. Annals of Gastroenterology, 31(6), 639–648. https://doi.org/10.20524/aog.2018.0314
Do, T., Diamond, S., Green, C., & Warren, M. (2021). Nutritional Implications of Patients with Dysautonomia and Hypermobility Syndromes. Current Nutrition Reports, 10(4), 324–333. https://doi.org/10.1007/s13668-021-00373-1
Du, L., Shen, J., Kim, J. J., He, H., Chen, B., & Dai, N. (2018). Impact of gluten consumption in patients with functional dyspepsia: A case-control study. Journal of Gastroenterology and Hepatology, 33(1), 128–133. https://doi.org/10.1111/jgh.13813
Duncanson, K. R., Talley, N. J., Walker, M. M., & Burrows, T. L. (2018). Food and functional dyspepsia: a systematic review. Journal of Human Nutrition and Dietetics, 31(3), 390–407. https://doi.org/10.1111/jhn.12506
Fedorowski, A. (2019). Postural orthostatic tachycardia syndrome: Clinical presentation, aetiology and management. Journal of Internal Medicine, 285(4), 352–366. https://doi.org/10.1111/joim.12852
Fragkos, K. C., Keetarut, K., Cox, A., Eady, J., Emmanuel, A. v., & Zarate-Lopez, N. (2019). Joint Hypermobility Syndrome Affects Response to a Low Fermentable Oligosaccharide, Disaccharide, Monosaccharide and Polyol Diet in Irritable Bowel Syndrome Patients: A Retrospective Study. Gastroenterology Research, 12(1), 27–36. https://doi.org/10.14740/gr1133
Gensemer, C., Burks, R., Kautz, S., Judge, D. P., Lavallee, M., & Norris, R. A. (2021). Hypermobile Ehlers‐Danlos syndromes: Complex phenotypes, challenging diagnoses, and poorly understood causes. Developmental Dynamics, 250(3), 318–344. https://doi.org/10.1002/dvdy.220
Grigoriou, E., Boris, J. R., & Dormans, J. P. (2015). Postural orthostatic tachycardia syndrome (Pots): Association with ehlers-danlos syndrome and orthopaedic considerations. Clinical Orthopaedics and Related Research, 473(2), 722–728. https://doi.org/10.1007/s11999-014-3898-x
Halmos, E. P., Christophersen, C. T., Bird, A. R., Shepherd, S. J., Gibson, P. R., & Muir, J. G. (2015). Diets that differ in their FODMAP content alter the colonic luminal microenvironment. Gut, 64(1), 93–100. https://doi.org/10.1136/gutjnl-2014-307264
Lam, C. Y., Palsson, O. S., Whitehead, W. E., Sperber, A. D., Tornblom, H., Simren, M., & Aziz, I. (2021). Rome IV Functional Gastrointestinal Disorders and Health Impairment in Subjects With Hypermobility Spectrum Disorders or Hypermobile Ehlers-Danlos Syndrome. Clinical Gastroenterology and Hepatology, 19(2), 277-287.e3. https://doi.org/10.1016/j.cgh.2020.02.034
Leganger, J., Fonnes, S., Kulas Søborg, M. L., Rosenberg, J., & Burcharth, J. (2022). The most common comorbidities in patients with Ehlers-Danlos syndrome: a 15-year nationwide population-based cohort study. Disability and Rehabilitation, 44(2), 189–193. https://doi.org/10.1080/09638288.2020.1761890
Mantle, D., Wilkins, R. M., & Preedy, V. (2005). A novel therapeutic strategy for Ehlers–Danlos syndrome based on nutritional supplements. Medical Hypotheses, 64(2), 279–283. https://doi.org/10.1016/j.mehy.2004.07.023
Nelson, A. D., Mouchli, M. A., Valentin, N., Deyle, D., Pichurin, P., Acosta, A., & Camilleri, M. (2015). Ehlers Danlos syndrome and gastrointestinal manifestations: a 20-year experience at Mayo Clinic. Neurogastroenterology & Motility, 27(11), 1657–1666. https://doi.org/10.1111/nmo.12665
Nordin, E., Brunius, C., Landberg, R., & Hellström, P. M. (2022). Fermentable oligo-, di-, monosaccharides, and polyols (FODMAPs), but not gluten, elicit modest symptoms of irritable bowel syndrome: a double-blind, placebo-controlled, randomized three-way crossover trial. The American Journal of Clinical Nutrition, 115(2), 344–352. https://doi.org/10.1093/ajcn/nqab337
Panteliadis, C. P. (2022). Ehlers-Danlos Syndrome. In Neurocutaneous Disorders (pp. 393–399). Springer International Publishing. https://doi.org/10.1007/978-3-030-87893-1_36
Pesce, M., Cargiolli, M., Cassarano, S., Polese, B., Conno, B. de, Aurino, L., Mancino, N., & Sarnelli, G. (2020). Diet and functional dyspepsia: Clinical correlates and therapeutic perspectives. World Journal of Gastroenterology, 26(5), 456–465. https://doi.org/10.3748/wjg.v26.i5.456
Potter, M. D. E., Duncaon, K., Jones, M. P., Walker, M. M., Keely, S., & Talley, N. J. (2020). Wheat Sensitivity and Functional Dyspepsia: A Pilot, Double-Blind, Randomized, Placebo-Controlled Dietary Crossover Trial with Novel Challenge Protocol. Nutrients, 12(7), 1947. https://doi.org/10.3390/nu12071947
Riley, B. (2020). The many facets of hypermobile ehlers-danlos syndrome. Journal of Osteopathic Medicine, 120(1), 30–32. https://doi.org/10.7556/jaoa.2020.012
Sánchez-Manso, J. C., Gujarathi, R., & Varacallo, M. (2022). Autonomic dysfunction. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK430888/
Song, B., Yeh, P., & Harrell, J. (2021). Systemic manifestations of Ehlers-Danlos syndrome. Baylor University Medical Center Proceedings, 34(1), 49–53. https://doi.org/10.1080/08998280.2020.1805714
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Staudacher, H. M., Nevin, A. N., Duff, C., Kendall, B. J., & Holtmann, G. J. (2021). Epigastric symptom response to low FODMAP dietary advice compared with standard dietetic advice in individuals with functional dyspepsia. Neurogastroenterology & Motility, 33(11). https://doi.org/10.1111/nmo.14148
van Lanen, A.-S., de Bree, A., & Greyling, A. (2021). Efficacy of a low-FODMAP diet in adult irritable bowel syndrome: a systematic review and meta-analysis. European Journal of Nutrition, 60(6), 3505–3522. https://doi.org/10.1007/s00394-020-02473-0
Wang, C., & Fang, X. (2021). Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia. Journal of Neurogastroenterology and Motility, 27(2), 153–164. https://doi.org/10.5056/jnm20175
Wang, H. (2021). A Review of the Effects of Collagen Treatment in Clinical Studies. Polymers, 13(22), 3868. https://doi.org/10.3390/polym13223868
Images
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